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Autoimmune expression profiling

Characterize immune dysfunction with the HTG EdgeSeq Autoimmune Panel for targeted, high-throughput gene expression profiling

Take a comprehensive look into immune system dysfunction in autoimmune disease and treatment-induced response events.

The HTG EdgeSeq Autoimmune Panel leverages the sensitivity and dynamic range of next-generation sequencing (NGS) to measure expression levels of 2,002 genes implicated in a variety of autoimmune diseases.

 

This panel was designed to provide critical insight into the following applications:

  • Evaluate pathways, processes, and cell types involved in autoimmune disease, chronic inflammatory disease, and abnormal immune response
  • Elucidate therapeutic mechanism of action or validate drug targets
  • Measure immunotherapy induced responses
  • Discover and validate disease- and therapeutic- specific biomarkers
  • Develop predictive signatures of drug response
Click or hover on any of the categories in the above chart to see the number of gene targets covered by the HTG EdgeSeq Autoimmune Panel

Therapeutic categories:

  • Type I interferon
  • Type II interferon
  • Innate and adaptive immune-related interleukins
  • Tumor necrosis factor (TNF)
  • Toll-like receptors
  • Immune cell signaling
  • Immune checkpoint and co-stimulatory targets
  • Other immunomodulatory agents

Disease-specific profiling:

  • Rheumatoid arthritis
  • Type 1 diabetes
  • Systemic lupus erythematosus
  • Ankylosing spondylitis
  • Crohn’s disease
  • Ulcerative colitis
  • Irritable bowel syndrome
  • Multiple sclerosis
  • Psoriasis

Assay validation report:

Interactive autoimmune explorer:

Explore HTG EdgeSeq Autoimmune Panel gene content, functional gene groups, and autoimmune disease states.

Click here to start exploring

ai-explorer-rna@2x

Autoimmune profiling supports the drug development lifecycle

The HTG EdgeSeq Autoimmune Panel can be used to evaluate pathways, processes, and cell types involved in autoimmune disease, chronic inflammatory disease, and abnormal immune response.

Biomarker discovery

Discovery & validation of disease and therapeutic- specific biomarkers

Drug
development

Target validation and therapeutic mechanism of action studies

Clinical trial monitoring

Immunotherapy induced response event investigations

CDx
development

Investigation of predictive signatures of drug response & IVD assay development

The HTG EdgeSeq Autoimmune Panel is ideally suited for gene expression analysis

sample-consumption

Minimal sample consumption

target

Expertly curated content

analysis

Powerful data analysis via
HTG EdgeSeq Reveal

hourglass

Semi-automated workflow reduces hands-on time

sequencer

Generate useful data with <1 million reads per sample

road-map

A path from clinical trials to an approved CDx

Small input requirements are ideal for your studies

  • Low input requirement  - only 500 µl PAXgene needed
  • Minimizes sample exhaustion
  • Ideal for retrospective or serial testing applications, where sample is limited.
droplet

Right-sized RNA profiling panel moves projects forward

  • Measure 2,002 genes, 38 processes, and signaling pathways
  • 9 prevalent autoimmune diseases and numerous general immune response genes

Sample to answer in as few as 36 hours

HTG-workflow-paxgene@2x

From data to insights

The HTG EdgeSeq Reveal software package allows you to quickly see meaningful results and reports without a complicated analysis pipeline.

Data analysis capabilities:

  • Normalization and principal component analysis tools
  • Quality control data and correlation results generated from HTG EdgeSeq assays
  • Enables research on biology and pathways
  • Easy visualization of gene expression profiles

Ready to get started?

Do the work in your lab, or outsource it to ours

services

Autoimmune profiling services

Our internal ISO:13485, VERI/O GLP lab offers sample processing services and molecular profiling studies.

These services are ideal for retrospective studies for our biopharma clients and academic collaborators in translational research.

assays

Autoimmune assay kits

HTG EdgeSeq assays contain all of the reagents and consumables to generate sequencing-ready NGS libraries for molecular profiling.

Assays may be run  in-house, at one of our Preferred Academic Centers of Excellence (PACE), or in our global network of Qualified Service Provider (QSP) laboratories.